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October 3, 2025Clinical ChemistryOpen Access

A-100 The evaluation of kidney injury molecule and neutrophil gelatinase associated lipocalin as predictive biomarkers of acute kidney injury in a subset of Jamaican patients undergoing cardiopulmonary bypass surgery

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Authors

SMShada MohansinghLDLowell DilworthDMDonovan McGrowder

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Overview

Prospective pilot study assesses NGAL and KIM-1 as biomarkers for AKI in patients undergoing cardiopulmonary bypass, indicating early detection importance.

Key Points

  • NGAL demonstrated excellent predictive ability for AKI at 2 hours post-surgery, with an AUC of 0.925.
  • Four patients developed AKI and prolonged cardiopulmonary bypass was a significant risk factor for these cases.
  • Serum creatinine levels rose early in AKI patients, with sensitivity and specificity improving significantly at 4 and 24 hours.
  • KIM-1 was not statistically significant for early AKI detection, highlighting the superiority of urine NGAL.

Cite This Study

Mohansingh et al. (2025) studied this question.

synapsesocial.com/papers/68e040e9a99c246f578b31c8https://doi.org/10.1093/clinchem/hvaf086.099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Prediction of Post-Cardiac-Surgery Acute Kidney Injury: Urinary NGAL versus Serum Creatinine2025
  2. 2Plasma neutrophil gelatinase-associated lipocalin protein and cystatin C as predictive biomarkers for acute kidney injury following cardiopulmonary bypass surgery: a prospective study2025
  3. 3Beyond creatinine: diagnostic accuracy of emerging biomarkers for AKI in the ICU – a systematic review2025 · 17 citations
  4. 4The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury2025 · 1 citations
  5. 5L-Carnitine, A new biomarker screened based on untargeted metabolomics, predict cardiac surgery-associated acute kidney injury: A prospective cohort study2025