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September 23, 2025Renal FailureOpen Access

Beyond creatinine: diagnostic accuracy of emerging biomarkers for AKI in the ICU – a systematic review

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Authors

AMAhmad MatarnehAAAbdelrauof AkkariSSSundus Sardar

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Overview

Systematic review assesses NGAL, KIM-1, and TIMP-2·IGFBP7's accuracy for AKI detection, indicating potential for better diagnostics.

Key Points

  • NGAL and TIMP-2·IGFBP7 show promising diagnostic performance for early AKI detection in ICU settings.
  • NGAL demonstrated sensitivity of 65-89% and specificity of 60-85%, indicating its effectiveness as a biomarker.
  • KIM-1 showed moderate diagnostic performance for AKI, with an area under the curve of 0.64-0.80.
  • Standardized multicenter studies are essential to validate the clinical utility and integration of these biomarkers.

Cite This Study

Matarneh et al. (2025) studied this question.

synapsesocial.com/papers/68d43eeb713b0b5dfea7efb1https://doi.org/10.1080/0886022x.2025.2556295
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