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August 15, 2025Pediatric NephrologyOpen Access

The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury

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Authors

WHWun Fung HuiRCRenee W. Y. ChanMTMan Tang

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Overview

Observational analysis reveals biomarkers significantly predict outcomes in pediatric acute kidney injury, indicating clinical relevance.

Key Points

  • All four urinary biomarkers significantly predicted kidney outcomes, with NGAL showing the best performance for both persistent and prolonged AKI outcomes.
  • The incidence of persistent and prolonged AKI was observed in 40.3% and 25.4% of 134 critically ill children, indicating serious implications in pediatric care.
  • Integrating urinary biomarkers with clinical data improved prediction accuracy, with an AUC of 0.86 for persistent AKI and 0.87 for prolonged AKI outcomes.
  • Persistent AKI increases the risk of kidney function non-recovery, with hazard ratios indicating significant long-term consequences for affected children.

Cite This Study

Hui et al. (2025) studied this question.

synapsesocial.com/papers/68a34f59234c60ad5c20ba3chttps://doi.org/10.1007/s00467-025-06920-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C as Early Biomarkers of Acute Kidney Injury in Critically Ill Children: Single-Center PICU Cohort, 2024–20252026
  2. 2Beyond creatinine: diagnostic accuracy of emerging biomarkers for AKI in the ICU – a systematic review2025 · 17 citations
  3. 3Comparative Performance of Novel and Standard Urinary Kidney Biomarkers for Prediction of Persistent Severe AKI and Long-Term Major Adverse Kidney Events2026
  4. 4A-100 The evaluation of kidney injury molecule and neutrophil gelatinase associated lipocalin as predictive biomarkers of acute kidney injury in a subset of Jamaican patients undergoing cardiopulmonary bypass surgery2025
  5. 5Diagnostic utility of urinary neutrophil gelatinase associated lipocalin (µNGAL) in predicting the severity of acute kidney injury2025