L-Carnitine, A new biomarker screened based on untargeted metabolomics, predict cardiac surgery-associated acute kidney injury: A prospective cohort study
Prospective cohort study found l-carnitine significantly predicts acute kidney injury in cardiac surgery patients, highlighting improved predictive performance with clinical models.
Key Points
Postoperative l-carnitine effectively predicts acute kidney injury in cardiac surgery patients.
AUC for postoperative l-carnitine in predicting acute kidney injury was 0.777, indicating strong predictive performance.
Multivariate logistic regression analysis identified preoperative heart failure and vasopressor-inotropic score as independent risk factors.
Serum biomarker analysis showed significant differences in l-carnitine levels between acute kidney injury and non-acute kidney injury groups.