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October 1, 2025The FASEB JournalOpen Access

HsacircRNA₀101125 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma via miR‐143‐3p/ZNF148 Axis

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Authors

HCHao ChenSXSongtao XueSCShuo‐Hui Cao

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Overview

Experimental data shows hsa_circRNA_0101125 boosts cell migration and invasion in esophageal squamous cell carcinoma, suggesting critical roles for miR-143-3p and ZNF148.

Key Points

  • Hsa_circRNA_0101125 promotes proliferation, migration, and invasion of esophageal squamous cell carcinoma cells.
  • Inhibition of hsa_circRNA_0101125 reduced cell viability, migration, and invasion while altering expression of ZNF148 and miR-143-3p.
  • The relationship between hsa_circRNA_0101125, miR-143-3p, and ZNF148 was confirmed through dual-luciferase assays and expression measurement techniques.
  • Findings support the idea that hsa_circRNA_0101125 acts through miR-143-3p to influence cancer cell behavior, highlighting potential therapeutic targets.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497e20https://doi.org/10.1096/fj.202500257r
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