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September 10, 2025Clinical and Experimental Dental ResearchOpen Access

Hsacirc₀005325 Regulates the Proliferation, Apoptosis, Colony Formation, Migration, and Angiogenesis‐Promoting Behavior of Oral Squamous Cell Carcinoma Cells Through the miR‐433‐3p/HMGA2 Axis

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Authors

ZLZhihan LinYFYating FuLMLei Mao

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Overview

Observational analysis shows that hsa_circ_0005325 affects proliferation and apoptosis in oral squamous cell carcinoma, indicating its role in tumor behavior.

Key Points

  • Downregulation of hsa_circ_0005325 leads to increased apoptosis and decreased proliferation in SCC25 and CAL-27 cells.
  • The expression of HMGA2 decreased while miR-433-3p expression increased after hsa_circ_0005325 knockdown.
  • Cell proliferation, migration, and angiogenesis capabilities were significantly reduced in hsa_circ_0005325 inhibited groups.
  • Findings suggest a critical role of hsa_circ_0005325 in the regulation of oral squamous cell carcinoma behaviors.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64782bd2https://doi.org/10.1002/cre2.70208
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