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September 10, 2025BMC GastroenterologyOpen Access

Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion

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Authors

GQGe QiaoCLChangjuan LiMWMeng Wang

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Overview

Analysis uncovered how hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts, promoting ESCC progression.

Key Points

  • Exosomal circNRIP1 activation of cancer-associated fibroblasts enhances migration and invasion of esophageal squamous cell carcinoma.
  • The hypoxic exosomes significantly increased secretion under low oxygen conditions, promoting tumor-associated characteristics.
  • RNA pull-down analysis revealed a binding interaction between circNRIP1 and TRMT6, essential for CAF activation.
  • This research positions hypoxia-induced circNRIP1 as a potential therapeutic target in esophageal squamous cell carcinoma.

Cite This Study

Qiao et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a47adhttps://doi.org/10.1186/s12876-025-03978-w
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