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September 10, 2025Journal of Oral Pathology and Medicine

The Function of Hsacirc₀001862 Regulating miR‐23a‐IRF1/PPP2R5E Axis to Oral Squamous Cell Carcinoma Development

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Authors

XLXue LiuHXHui XiongXWXuefeng Wang

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Overview

This research uncovers the hsa_circ_0001862-miR-23a-IRF1/PPP2R5E signaling in oral squamous cell carcinoma, highlighting its impact.

Key Points

  • Hsa_circ_0001862 is found to regulate miR-23a's expression, linking it to oral squamous cell carcinoma.
  • Increased levels of miR-23a in tumor tissues correlate with lower expression of its target genes IRF1 and PPP2R5E.
  • A series of cell phenotype experiments demonstrated the role of these genes in the progression of tongue squamous cell carcinoma.
  • The identified signaling pathway provides a foundation for early detection and potential treatments for oral squamous cell carcinoma.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea61948https://doi.org/10.1111/jop.70013
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