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September 10, 2025Technology and Health Care

A new target for the treatment of oral squamous cell carcinoma: Circ₀046336

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Authors

JCJi‐Jun ChenLWLiang WangDMDanhua Ma

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Overview

Research shows Circ_0046336 regulates apoptosis and migration in OSCC, indicating a new therapeutic target.

Key Points

  • Circ_0046336 silencing facilitates apoptosis in oral squamous cell carcinoma cells, reducing their viability.
  • The expression of miR-181d-3p was upregulated and ADAM12 downregulated as a result of Circ_0046336 knockdown.
  • Circ_0046336 acts as a ceRNA, influencing epithelial-mesenchymal transition-related proteins in OSCC cells.
  • The effects of Circ_0046336 on OSCC behaviors are reversed by miR-181d-3p deficiency, highlighting its regulatory role.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d647a037chttps://doi.org/10.1177/09287329251363708
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