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July 15, 2025

Data from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Research demonstrates that circRNA circTMEM45A activates NLRP3 inflammatory signaling in esophageal cancer, suggesting new diagnostic targets.

Key Points

  • MAIN FINDING: Elevated levels of circTMEM45A are linked to advanced stages of esophageal cancer, indicating its role in malignancy.
  • KEY EVIDENCE: The study shows that circTMEM45A modulates m5C modifications to promote NLRP3 activation and IL1β signaling in tumor cells.
  • APPROACH: The research utilized both in vitro and in vivo models to investigate the function of circTMEM45A in esophageal squamous cell carcinoma.
  • SIGNIFICANCE: Targeting circTMEM45A may enhance diagnosis and treatment strategies in patients with esophageal cancer.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc63chttps://doi.org/10.1158/0008-5472.c.7928366
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 2 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025