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June 27, 2026Pediatric Critical Care Medicine

Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C as Early Biomarkers of Acute Kidney Injury in Critically Ill Children: Single-Center PICU Cohort, 2024–2025

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Authors

AFAna Rita Fradique MFMariana Ferreira ARAlexandra Costa Rodrigues

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Overview

Single-center cohort study identifies urinary biomarkers for early detection of AKI in critically ill children, suggesting effective diagnostic tools.

Key Points

This study aims to evaluate urinary neutrophil gelatinase-associated lipocalin and serum cystatin C as early biomarkers for acute kidney injury in critically ill children.
Single-center cohort study conducted in a pediatric intensive care unit (PICU).
Analyzed 75 patients over 10 months, focusing on biomarkers and clinical parameters associated with AKI.
Measured uNGAL and Cys-C levels on days 1-3 to assess their relationship with AKI development.
AKI developed in 22 patients (29.3%); uNGAL showed significant elevation on days 1, 2, and 3 (p < 0.001, p = 0.003, p = 0.013 respectively).
Cystatin C was elevated on day 1 only (p = 0.013); good-to-excellent discrimination for AKI with uNGAL (AUC 0.847) and blood urea nitrogen (AUC 0.848).
Diagnostic uncertainty remained with a 29.3% pretest probability of AKI, rising to 73.1% posttest with uNGAL >87 ng/mL.

Cite This Study

Fradique et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f357 https://doi.org/10.1097/pcc.0000000000003984

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June 27, 2026Pediatric Critical Care Medicine

Urinary Neutrophil Gelatinase-Associated Lipocalin and Serum Cystatin C as Early Biomarkers of Acute Kidney Injury in Critically Ill Children: Single-Center PICU Cohort, 2024–2025

View Full Paper

Ask AI

Bookmark

Authors

AFAna Rita Fradique MFMariana Ferreira ARAlexandra Costa Rodrigues

Discussion

Member takes

Overview

Single-center cohort study identifies urinary biomarkers for early detection of AKI in critically ill children, suggesting effective diagnostic tools.

Key Points

This study aims to evaluate urinary neutrophil gelatinase-associated lipocalin and serum cystatin C as early biomarkers for acute kidney injury in critically ill children.
Single-center cohort study conducted in a pediatric intensive care unit (PICU).
Analyzed 75 patients over 10 months, focusing on biomarkers and clinical parameters associated with AKI.
Measured uNGAL and Cys-C levels on days 1-3 to assess their relationship with AKI development.
AKI developed in 22 patients (29.3%); uNGAL showed significant elevation on days 1, 2, and 3 (p < 0.001, p = 0.003, p = 0.013 respectively).
Cystatin C was elevated on day 1 only (p = 0.013); good-to-excellent discrimination for AKI with uNGAL (AUC 0.847) and blood urea nitrogen (AUC 0.848).
Diagnostic uncertainty remained with a 29.3% pretest probability of AKI, rising to 73.1% posttest with uNGAL >87 ng/mL.

Cite This Study

Fradique et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f357 https://doi.org/10.1097/pcc.0000000000003984

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