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January 9, 2026DiagnosticsOpen Access

Biomarker-guided care bundles reduced AKI incidence in surgical populations, indicating potential for improved early detection and outcomes in perioperative care.

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Key result

Biomarker-guided care bundles reduced AKI incidence in surgical populations, indicating potential for improved early detection and outcomes in perioperative care.

Authors

KZKonrad ZuzdaPWPaulina Walczak-WieteskaPAPaweł Andruszkiewicz

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Overview

This scoping review examines novel AKI biomarkers and their clinical implementation in surgical settings, indicating potential for improved patient outcomes.

Key Points

  • The review aims to assess the current state of novel biomarkers for early detection of AKI and their clinical usage in perioperative care.
  • Conducted a systematic search for studies on novel AKI biomarkers in surgical settings.
  • Categorized biomarkers into functional, stress, or damage markers.
  • Extracted data on diagnostic performance, clinical outcomes, regulatory approval, and implementation barriers.
  • Organized narrative synthesis by biomarker category and thematic areas.
  • Several biomarkers showed better early diagnostic performance than traditional methods, including PENK and CCL-14.
  • TIMP-2*IGFBP-7 and NGAL received regulatory approval.
  • Biomarker-guided KDIGO care bundles significantly reduced AKI incidence in surgical populations.
  • Noted heterogeneity in assays, cutoff values, and clinical validation across different settings.

Cite This Study

Zuzda et al. (2025) studied this question. Biomarker-guided care bundles reduced AKI incidence in surgical populations, indicating potential for improved early detection and outcomes in perioperative care.

synapsesocial.com/papers/69612fe130ef6c21f6853ec6https://doi.org/10.3390/diagnostics16010094
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Also Consider

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  4. 4Comparative Performance of Novel and Standard Urinary Kidney Biomarkers for Prediction of Persistent Severe AKI and Long-Term Major Adverse Kidney Events2026
  5. 5The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury2025 · 1 citations