Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 23, 2025International Journal of Molecular SciencesOpen Access

High-Fat Diet Alters Behavior and Hippocampal Gene Expression

View Full Paper
Ask AI
Bookmark
Share

Authors

MTMelissa S. TottenAPAC PetersonDPDerek Pierce

Discussion

Loading...

Member takes

Overview

Study shows high-fat diet influences behavior and gene expression in male mice, highlighting sex differences.

Key Points

  • The high-fat diet caused significant behavior changes, primarily in male B6J mice, impacting their anxiety and welfare activities.
  • Significant changes in mRNA expression of alpha synuclein and amyloid precursor protein were observed in male B6J mice on a high-fat diet.
  • Behavioral tests revealed reduced nestlet shredding and no memory differences across the strains, indicating strain-specific effects.
  • The findings suggest that sex and genetic factors are crucial for understanding the effects of diet on brain function and behavior.

Cite This Study

Totten et al. (2025) studied this question.

synapsesocial.com/papers/68d43eeb713b0b5dfea7ee39https://doi.org/10.3390/ijms26189241
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease2025
  2. 2Sex Specific Effects of a High Fat Diet on Metabolism, Cognition, and Pathology in the Tg-SwDI Mouse Model of Alzheimer’s Disease2025
  3. 3Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice2025
  4. 4Effect of high-fat diet in female rats on physiological, biochemical and hematological parameters in first generation offspring2025
  5. 5Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice2025