Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 15, 2025Journal of Alzheimer s Disease ReportsOpen Access

Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease

View Full Paper
Ask AI
Bookmark
Share

Authors

KGKuppan GokulanKKKumari KarnSSSumit Sarkar

Discussion

Loading...

Member takes

Overview

This research finds increased mRNA expression related to Alzheimer's in rats fed a high-fat diet, suggesting connections to gut health.

Key Points

  • HFD consumption led to increased mRNA expression of Alzheimer's disease genes in wild-type rats, indicating diet's role in AD development.
  • Transgenic female rats on HFD displayed more upregulated genes compared to controls, suggesting heightened vulnerability to AD progression.
  • Assessment involved feeding WT and TG rats a control or high-fat diet, then analyzing ileal tissues for gene expression.
  • Overall findings highlight the gut-brain axis' importance in Alzheimer's disease development and progression, especially in females.

Cite This Study

Gokulan et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771de6https://doi.org/10.1177/25424823251358414
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex Specific Effects of a High Fat Diet on Metabolism, Cognition, and Pathology in the Tg-SwDI Mouse Model of Alzheimer’s Disease2025
  2. 2High-Fat Diet Alters Behavior and Hippocampal Gene Expression2025
  3. 3Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet2025
  4. 4Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model2025
  5. 5Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes2025