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October 12, 2025Open Access

Sex Specific Effects of a High Fat Diet on Metabolism, Cognition, and Pathology in the Tg-SwDI Mouse Model of Alzheimer’s Disease

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Authors

SSShelby SabourinCTChristina A ThrasherRSRachel M. Smith

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Overview

Analysis reveals that high fat diet differentially impacts cognition and pathology in male and female Alzheimer’s mice, suggesting metabolic syndrome plays a distinct role.

Key Points

  • AD females showed greater cognitive and metabolic disturbances on a high fat diet than males.
  • HFD led to increased anxiety and impaired memory in both sexes, particularly in females with Alzheimer's disease.
  • Microglial activation and amyloid pathology in the thalamus were exacerbated in HFD-fed female AD mice.
  • Findings suggest that sex differences in response to metabolic conditions may alter Alzheimer's disease progression.

Cite This Study

Sabourin et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff23a3https://doi.org/10.21203/rs.3.rs-7686971/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease2025
  2. 2Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes2025
  3. 3High-Fat Diet Alters Behavior and Hippocampal Gene Expression2025
  4. 4Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease2025
  5. 5Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model2025