Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025AJP Cell Physiology

Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice

View Full Paper
Ask AI
Bookmark
Share

Authors

VRVicent RibasSMSamantha Morón‐RosHMHelena Marí

Discussion

Loading...

Member takes

Overview

Analysis reveals metabolic dysfunction effects from diet-induced obesity in male and female mice, suggesting critical gene role.

Key Points

  • HFD-fed males showed more severe metabolic impairments than females despite similar adiposity.
  • Significant downregulation of male-biased genes was observed in male WAT under HFD conditions.
  • Whole transcriptomic profiling revealed marked sex-specific gene expression changes during obesity.
  • A considerable portion of sex-biased genes underwent modulation due to HFD exposure, correlating with metabolic health.

Cite This Study

Ribas et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479d3f3https://doi.org/10.1152/ajpcell.00098.2025
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex Disparities in Obesity: A Comprehensive Review of Hormonal and Genetic Influences on Obesity‐Related Phenotypes2025
  2. 2Epigenetic regulation role of SUV420H in sexual dimorphism of adipose tissue and obesity2025
  3. 3Ovarian hormones and high‐fat diet duration distinctively modulate hypothalamic chemokine profile2026
  4. 4The metabolic advantage of being young and male in obesity treatment outcomes in mice2025
  5. 5High-Fat Diet Alters Behavior and Hippocampal Gene Expression2025