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September 11, 2025NeuroSciOpen Access

From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease

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Authors

HPHaylie J. PomroyAMArjun MoteSMShilpa Mathew

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Overview

This review examines AGE-RAGE signaling pathways and dietary sources, suggesting dietary AGE restriction may slow neurodegenerative disease progression.

Key Points

  • Sustained AGE-RAGE signaling contributes to chronic inflammation, worsening neurodegenerative diseases.
  • AGEs cause cellular damage by generating reactive oxygen species and inducing mitochondrial dysfunction.
  • This review discusses the formation and metabolism of AGEs with a focus on modifiable dietary factors.
  • Further exploration of dietary AGE restriction could help prevent or slow the progression of neuroinflammatory disorders.

Cite This Study

Pomroy et al. (2025) studied this question.

synapsesocial.com/papers/68d43b02713b0b5dfea7b056https://doi.org/10.3390/neurosci6030089
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective2025
  2. 2Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective2025
  3. 3Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review2025 · 13 citations
  4. 4The Role of Advanced Glycation End-Products in the Pathophysiology and Pharmacotherapy of Cardiovascular Disease2025
  5. 5The roles of advanced glycation end products in cardiovascular diseases: from mechanisms to therapeutic strategies2025 · 7 citations