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August 11, 2025Open Access

Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective

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Authors

VBVirginia BoccardiFMFrancesca MancinettiPMPatrizia Mecocci

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Overview

Narrative review uncovers the role of oxidative stress and AGEs in neurodegeneration, suggesting new therapeutic targets.

Key Points

  • Oxidative stress and advanced glycation end products contribute to neuronal damage in Alzheimer's disease, advancing the understanding of disease mechanisms.
  • Preclinical and clinical studies reveal the significant roles of reactive oxygen species and AGEs in exacerbating neurodegeneration.
  • The narrative review discusses therapeutic strategies like antioxidants and AGE inhibitors that target mitochondrial dysfunction.
  • This research highlights a unified pathway of oxidative and glycative stress, emphasizing its clinical significance and potential for personalized treatments.

Cite This Study

Boccardi et al. (2025) studied this question.

synapsesocial.com/papers/68c2354db210217d647706a5https://doi.org/10.20944/preprints202507.1256.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective2025 · 23 citations
  2. 2Therapeutic Challenges and Perspectives in Alzheimer’s Disease: A Critical Review of the AGE-RAGE Axis, Oxidative Stress, and Metabolic Dysfunctions2025
  3. 3From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease2025 · 9 citations
  4. 4Perspectives on Alzheimer’s Disease Treatment Based on Counteracting Oxidative Stress2025 · 10 citations
  5. 5Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy2025 · 8 citations