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September 5, 2025Frontiers in Cardiovascular MedicineOpen Access

The roles of advanced glycation end products in cardiovascular diseases: from mechanisms to therapeutic strategies

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Authors

ZLZhou-Suan LiXWXinyao WangQLQi Luo

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Overview

This review examines advanced glycation end products' roles and mechanisms in cardiovascular diseases, highlighting emerging therapeutic strategies.

Key Points

  • Advanced glycation end products significantly contribute to cardiovascular diseases by inducing oxidative stress and inflammation.
  • Both endogenous and exogenous advanced glycation end products affect cardiovascular tissues, leading to dysfunction and complications.
  • The pathways mediated by the AGE-RAGE axis are crucial in understanding the impact of advanced glycation end products on heart health.
  • Strategies to mitigate the effects of advanced glycation end products in cardiovascular diseases offer potential for new therapeutic approaches.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477c7aahttps://doi.org/10.3389/fcvm.2025.1637252
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