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August 25, 2025AntioxidantsOpen Access

Oxidative Stress, Advanced Glycation End Products (AGEs), and Neurodegeneration in Alzheimer’s Disease: A Metabolic Perspective

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Authors

VBVirginia BoccardiFMFrancesca MancinettiPMPatrizia Mecocci

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Overview

Narrative review highlights neurodegeneration mechanisms in Alzheimer’s disease, suggesting potential therapeutic targets.

Key Points

  • Oxidative stress combined with advanced glycation end products drives neurodegeneration in Alzheimer’s disease.
  • Findings from preclinical and clinical studies show their significant roles in disease progression and therapeutic interventions.
  • Narrative review discusses metabolic impacts of reactive oxygen species and advanced glycation end products in Alzheimer's.
  • Identifying potential therapeutic targets may enable new strategies for personalized treatments in neurodegenerative diseases.

Cite This Study

Boccardi et al. (2025) studied this question.

synapsesocial.com/papers/68af7b1f7567bf4f94ff2b15https://doi.org/10.3390/antiox14091044
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