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September 19, 2025PLoS ONEOpen Access

Super-enhancer-associated LINC00963 promotes metastasis of gastric cancer through epithelial-mesenchymal transition

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Authors

HDHong DuTXT. XiangYXYing Xia

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Overview

Observational analysis reveals LINC00963 promotes metastasis in gastric cancer, indicating a role of super-enhancers in tumor progression.

Key Points

  • LINC00963 promotes metastasis in gastric cancer through epithelial-mesenchymal transition.
  • High expression of LINC00963 driven by super-enhancer was noted in gastric cancer cell lines.
  • Down-regulation of LINC00963 led to decreased expression of EMT-related proteins.
  • Transwell assays confirmed that LINC00963 increases invasion and migration of gastric cancer cells.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68d436ef713b0b5dfea761f4https://doi.org/10.1371/journal.pone.0332396
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