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September 10, 2025Jentashapir Journal of Cellular and Molecular BiologyOpen Access

Long Intergenic Non-coding RNA — LINC00659 — Expression Changes in Gastric Cancer: Lessons from Northwestern Iran

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Authors

EAElmira AbdolzadehEAEsmat AbdiSLSaeid Latifi‐Navid

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Overview

Assessment of LINC00659 expression reveals diagnostic potential in gastric cancer patients from Ardabil, suggesting its role as a biomarker.

Key Points

  • LINC00659 expression is significantly associated with tumor origin in gastric cancer patients.
  • Down-regulation of LINC00659 was observed more frequently in gastric cancer samples compared to controls, with a fold change of 0.57.
  • Real-time qRT-PCR was used to evaluate LINC00659 expression across 82 samples of tumor and adjacent non-cancerous tissues.
  • Further studies are needed with larger, diverse samples from Iran to verify the findings and understand LINC00659's role in gastric cancer.

Cite This Study

Abdolzadeh et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479ea3dhttps://doi.org/10.5812/jjcmb-153640
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1LINC00888 Promotes Gastric Cancer Growth and Metastasis by Sponging miR-145-5p to Regulate FZD7 Expression2025
  2. 2Identification of lncRNA <i>HCCAT5</i> as a Novel Biomarker for Gastric Cancer2025
  3. 3Diagnostic value of lnc-RNAs TINCR, GC1 and AFAP1-AS1 in gastric cancer differentiation from healthy people2025
  4. 4Super-enhancer-associated LINC00963 promotes metastasis of gastric cancer through epithelial-mesenchymal transition2025
  5. 5Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A Systematic Review and Meta-Analysis2025