Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 13, 2025The Kaohsiung Journal of Medical SciencesOpen Access

GLIS2 Promotes Epithelial‐Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β‐Catenin Pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

JYJuan YanYDYaoliang Deng

Discussion

Loading...

Member takes

Overview

Study shows GLIS2 promotes epithelial-mesenchymal transition in gastric cancer, activating Wnt/β-catenin through biglycan.

Key Points

  • GLIS2 promotes gastric cancer cell migration and invasion by activating the Wnt/β-catenin pathway.
  • Analysis of 18 pairs of gastric cancer tissues demonstrated GLIS2 enhances biglycan transcription.
  • In vitro models revealed that BGN overexpression reverses inhibitory effects of GLIS2 knockdown.
  • Inhibiting the Wnt/β-catenin pathway blocked biglycan's tumor-promoting effects in gastric cancer.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea685f0https://doi.org/10.1002/kjm2.70103
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries2021 · 114,619 citations