Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 12, 2025Frontiers in Bioscience-LandmarkOpen Access

LINC01605 Suppresses Esophageal Squamous Carcinogenesis by Regulating Squamous Cell Differentiation, Proliferation, and Migration

View Full Paper
Ask AI
Bookmark
Share

Authors

XCXian ChengXHXu HanHAHaiyin An

Discussion

Loading...

Member takes

Overview

Multistage analysis shows LINC01605 regulates squamous cell differentiation and migration in ESCC, suggesting its tumor suppressor role.

Key Points

  • LINC01605 acts as a tumor suppressor, inhibiting proliferation and migration in esophageal squamous cell carcinoma.
  • Downregulation of LINC01605 correlates with higher histological grade in esophageal tissues, indicating its importance in cancer progression.
  • Functional experiments revealed that silencing LINC01605 increased unwanted cell behaviors while overexpression suppressed them.
  • RNA pull-down assays identified interactions between LINC01605 and aurora kinase B, hinting at its role in cell cycle regulation.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad310https://doi.org/10.31083/fbl42805
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Super-enhancer-associated LINC00963 promotes metastasis of gastric cancer through epithelial-mesenchymal transition2025
  2. 2LINC01106 Stimulates Growth And Metastasis Of Colorectal Carcinoma By Sponging MiR-744-5p2025
  3. 3Hsa_circRNA_0101125 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma via <scp>miR</scp>‐143‐3p/<scp>ZNF148</scp> Axis2025
  4. 4354. A GENOMIC ANALYSIS OF SQUAMOUS CELL CARCINOMA OF THE OESOPHAGUS FOLLOWING NEOADJUVANT CHEMOTHERAPY2025
  5. 5The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance2025