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September 12, 2025Current Issues in Molecular BiologyOpen Access

Resina Draconis Promotes Diabetic Wound Healing by Regulating the AGE-RAGE Pathway to Modulate Macrophage Polarization

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Authors

XJXin JinALAng LiZDZhaoyuan Dai

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Overview

Network pharmacology analysis identifies therapeutic targets involving the AGE-RAGE pathway, suggesting it may combat diabetic wounds.

Key Points

  • Resina draconis significantly enhances diabetic wound healing in mouse models by regulating macrophage polarization.
  • In vitro analysis showed RD reduced inflammatory factors by downregulating AGE-induced RAGE protein overexpression.
  • Network pharmacology identified 492 potential therapeutic targets linked to the AGE-RAGE pathway for wound treatment.
  • Utilizing a diabetic wound mouse model, RD demonstrated its regulatory effects on oxidative stress and macrophages.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68d41c09713b0b5dfea658a3https://doi.org/10.3390/cimb47090748
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