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September 10, 2025NutrientsOpen Access

Early Caffeine Exposure Causes Metabolic and Hormonal Changes Differently According to the Window of Exposure (Gestation or Lactation), Sex, and Age in a Rat Model

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Authors

LSLuana L. SouzaRMRosiane Aparecida MirandaIBIala Milene Bertasso

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Overview

Observational analysis shows metabolic changes in offspring with caffeine intake during gestation or lactation, indicating different obesity risks.

Key Points

  • Caffeine exposure during lactation increases obesity risk in female offspring and lowers T3 hormone levels.
  • Male offspring of caffeine-exposed mothers exhibited lower T3 levels and increased feed efficiency, jumping ahead with metabolic overload.
  • Pregnant Wistar rats received caffeine or vehicle during either gestation or lactation to assess metabolic impacts on offspring.
  • Results highlight different susceptibilities to obesity based on sex and timing of caffeine exposure, calling for further investigation.

Cite This Study

Souza et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a6d90https://doi.org/10.3390/nu17172763
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