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September 17, 2025Pharmacological ReportsOpen Access

Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring

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Authors

KWKacper WitekKWKarolina WydraASAgata Suder

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Overview

This study demonstrates the impact of maternal monosaccharide diets on MC4R signaling and metabolic health in offspring.

Key Points

  • Maternal fructose diet increased sucrose consumption and dysregulated glucose homeostasis in male offspring.
  • Offspring exhibited significant changes in MC4R signaling and metabolic profiles based on maternal diet type.
  • Neurochemical analysis showed altered MC4R protein levels in critical brain regions related to metabolism and behavior.
  • Principal component analysis revealed distinct metabolic profiling based on diet and sex of the offspring.

Cite This Study

Witek et al. (2025) studied this question.

synapsesocial.com/papers/68d42f63713b0b5dfea70a2dhttps://doi.org/10.1007/s43440-025-00785-8
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  5. 5Maternal sucrose intake during pregnancy alone disrupts testosterone and allopregnanolone levels in the fetal brain of rats2025