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December 6, 2025Biology of Reproduction

Postnatal High-Fat Diet Consumption by Male Rat Offspring of Obese Mothers Accentuates Negative Outcomes of Reproductive Function in Young Adults

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Authors

DMDayana Méndez-SánchezLRLuis A. Reyes‐CastroGHGabriela Hernández‐Silva

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Overview

Maternal obesity exacerbates fertility decline in male offspring consuming high-fat diet, indicating severe health risks.

Key Points

  • Fertility significantly decreases in male offspring of mothers with obesity when a high-fat diet is consumed.
  • Reactive oxygen species levels elevated in offspring, alongside increased malondialdehyde concentrations indicative of oxidative stress.
  • Analysis conducted on male rat models experiencing varying dietary conditions post-weaning demonstrating reproductive dysfunction.
  • Maternal obesity may lead to profound negative consequences on health, necessitating further investigation into dietary impacts.

Cite This Study

Méndez-Sánchez et al. (2025) studied this question.

synapsesocial.com/papers/69337cdbb3f947a0a1259ec0https://doi.org/10.1093/biolre/ioaf261
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