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December 4, 2025Physiological ReportsOpen Access

Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats

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Authors

ARAntônio Augusto Coppi Maciel Ribeiro

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Overview

Experiment reveals maternal nutrition alters kidney function and metabolic health in offspring, suggesting risks for later diseases.

Key Points

  • Pregnant dams consuming fructose altered kidney function and liver health in their female offspring, indicating significant developmental impacts.
  • High fructose intake led to increased water retention and liver fat in female rats, highlighting sex-specific metabolic changes.
  • Assessment of placental anatomy in offspring links high maternal fructose consumption to long-term health risks.
  • These findings underscore the need to address maternal nutrition to prevent metabolic diseases in future generations.

Cite This Study

Antônio Augusto Coppi Maciel Ribeiro (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca1f60https://doi.org/10.14814/phy2.70684
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  4. 4Early Caffeine Exposure Causes Metabolic and Hormonal Changes Differently According to the Window of Exposure (Gestation or Lactation), Sex, and Age in a Rat Model2025
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