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January 9, 2026Journal of Clinical MedicineOpen Access

Inflammatory Reactions Within the Epicardial Adipose Tissue Are Associated with the Expression of the Receptor for Advanced Glycation End Products in Aortic Stenosis

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Key result

In patients with aortic stenosis, epicardial adipose tissue showed increased macrophage infiltration and RAGE expression, indicating its role in local inflammation.

Authors

AOA OryojiKSKosuke SakuNTNobuhiro Tahara

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Overview

Observational study finds inflammation in epicardial adipose tissue correlates with RAGE expression in aortic stenosis, suggesting new therapeutic targets.

Key Points

  • This study investigates the relationship between inflammatory activity in epicardial adipose tissue and RAGE expression in aortic stenosis patients.
  • Analyzed 42 patients with aortic stenosis and additional coronary artery disease undergoing surgery, alongside 10 autopsy controls.
  • Assessed epicardial adipose tissue volume via computed tomography, indexed to body surface area.
  • Used immunohistochemistry and immunofluorescence to evaluate macrophage infiltration and RAGE expression in adipose samples.
  • Epicardial adipose tissue volume index was significantly higher in surgical groups compared to controls (p < 0.001).
  • Increased CD68- and RAGE-positive cells were found in surgical groups compared to controls (p < 0.001).
  • A positive correlation was found between epicardial adipose tissue volume and CD68-positive cell counts (p = 0.021).
  • Causal mediation analysis suggested RAGE mediates macrophage activation pathways (p = 0.024).

Cite This Study

Oryoji et al. (2026) studied this question. In patients with aortic stenosis, epicardial adipose tissue showed increased macrophage infiltration and RAGE expression, indicating its role in local inflammation.

synapsesocial.com/papers/696128ef44c2cd6c68456bf9https://doi.org/10.3390/jcm15020428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Epicardial Adipose Tissue and Ischemic Stroke Risk: A Systematic Review and Meta-Analysis2025
  2. 2The Role of Advanced Glycation End-Products in the Pathophysiology and Pharmacotherapy of Cardiovascular Disease2025
  3. 3Mechanisms of AGE-induced VSMC phenotypic switching and macrophage modulation in human abdominal aortic aneurysms2025
  4. 4Recent Advances in Inflammation-Associated Epicardial Adipose Tissue for Atrial Fibrillation Patients2025
  5. 5Increase epicardial fat thickness predictors in stable coronary artery disease patients with borderline coronary artery stenosis2025