September 10, 2025Orthopaedic Proceedings

Multiomics Mapping and Characterization of Cellular Senescence in Ageing Human Skeletal Muscle Uncovers a Novel Senotherapeutic for Sarcopenia

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HWHuating WangChinese University of Hong Kong

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Implication

This study uncovers senescence dynamics in skeletal muscle, highlighting senescence-associated secretory phenotypes (SASPs) and implications for sarcopenia treatment.

Key Points

Cellular senescence plays a crucial role in aging skeletal muscle and contributes significantly to sarcopenia.
The research reveals variations in SASPs among muscle cells, showing how they influence cellular interactions and tissue regulation.
Using single-nucleus multiomics, the study provides a comprehensive atlas of cellular senescence in human muscle.
Pharmacological targeting of SASP factors, specifically with Maraviroc, shows potential in treating age-associated sarcopenia.

Cite This Study

Huating Wang (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478ca8e https://doi.org/10.1302/1358-992x.2025.6.070

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Implication

This study uncovers senescence dynamics in skeletal muscle, highlighting senescence-associated secretory phenotypes (SASPs) and implications for sarcopenia treatment.

Multiomics Mapping and Characterization of Cellular Senescence in Ageing Human Skeletal Muscle Uncovers a Novel Senotherapeutic for Sarcopenia

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiomics Mapping and Characterization of Cellular Senescence in Ageing Human Skeletal Muscle Uncovers a Novel Senotherapeutic for Sarcopenia

Discussion

Member takes

Implication

Key Points

Cite This Study

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