Abstract Thu091: Unraveling the Role of the Senescence-Associated Secretory Phenotype in Cardiac Aging Through Meta-Analysis and Experimental Validation

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Discussion

Meta-analysis reveals the role of senescence-associated secretory phenotype in cardiac aging, indicating potential therapeutic targets.

The study identifies the senescence-associated secretory phenotype as prevalent in non-cardiomyocytes during cardiac aging, which impacts heart function.
Through single-cell analysis, significant aging response heterogeneity among non-cardiomyocytes was documented across various age stages in mice.
The research employs dual-omics approaches to explore the interaction between non-cardiomyocytes and cardiomyocytes in relation to inflammatory and fibrotic processes.
Findings suggest that targeting key driver genes related to the senescence-associated secretory phenotype could lead to new therapies for age-related heart dysfunction.

Song et al. (2025) studied this question.

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