Mapping Human Muscle Cell Dynamics: From Development to Ageing

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Observational analysis reveals distinct aging phenotypes in muscle cells, highlighting roles of stem cells and microenvironments.

Cellular changes in skeletal muscle aging were uncovered, showing distinct aging phenotypes linked to stem cells.
Distinct subsets of muscle stem cells exhibited decreased ribosome biogenesis and increased CCL2 expression.
Atlas creation demonstrated two rounds of myogenesis early in human development, each regulated by unique transcription factors.
Insights into the role of the aging muscle microenvironment in immune cell attraction may inform therapeutic strategies.

Hongbo Zhang (2025) studied this question.

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