Molecular Pathogenesis of Sarcopenia: Regulatory Networks Involving MicroRNAs in Age-Related Skeletal Muscle Decline

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This review highlights the role of microRNAs in sarcopenia, revealing connections to oxidative stress and inflammation.

Sarcopenia significantly contributes to frailty and disability in aging populations, impacting quality of life.
MicroRNAs are crucial in regulating muscle homeostasis by influencing pathways related to muscle atrophy and inflammation.
Despite non-pharmacological strategies like resistance training, treatment effectiveness diminishes with aging.
Identifying microRNAs as biomarkers may improve early diagnosis and lead to more personalized treatment approaches.

Kalan et al. (2025) studied this question.

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