This review highlights cellular senescence's role in age-related diseases, suggesting targeted interventions like senolytic drugs may improve outcomes.
Key Points
Cellular senescence is a key driver of age-related diseases such as cardiovascular, neurodegenerative, and musculoskeletal disorders.
Senescence leads to irreversible cell cycle arrest and the release of inflammatory factors, disrupting tissue homeostasis.
Interventions like senolytic drugs and regular exercise may help target cellular senescence and improve health outcomes.
Understanding the mechanisms of cellular senescence is crucial for developing effective precision medicine strategies for aging populations.