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September 10, 2025Diseases of the Esophagus

Multi-Center Clinical Analysis and Single-Cell Sequencing Insights Into the Developmental Mechanisms of Synchronous Multiple Primary Esophageal Squamous Cell Carcinoma

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Authors

XLXiang LiYYYu‐Shang YangJWJian Wang

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Overview

Multi-center analysis identifies prognostic factors and unique tumorigenesis mechanisms in M-ESCC, indicating severe malignancy.

Key Points

  • M-ESCC is associated with significantly poorer outcomes compared to S-ESCC, underscoring its aggressive nature.
  • Among 7126 esophagectomy cases, 102 patients with M-ESCC were compared to 204 with S-ESCC, revealing distinct clinical features.
  • Single-cell sequencing uncovered unique immune microenvironments that may play a role in M-ESCC progression and severity.
  • Further exploration of epithelial subpopulations points to new pathways for therapeutic strategies targeting M-ESCC.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b916https://doi.org/10.1093/dote/doaf061.015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus2025
  2. 2475. COMPREHENSIVE GENOMIC AND TRANSCRIPTOMIC ANALYSES REVEAL PROGNOSTIC STRATIFICATION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  3. 3Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma2025
  4. 4Case Report: Genomic insights and personalized treatment in dual primary esophageal squamous cell carcinoma and gastric adenocarcinoma2025
  5. 5Whole-exome sequencing in a patient with a history of esophageal squamous cell carcinoma to discriminate recurrent disease from a second primary tumor2025