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September 10, 2025Discover OncologyOpen Access

Whole-exome sequencing in a patient with a history of esophageal squamous cell carcinoma to discriminate recurrent disease from a second primary tumor

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Authors

GZGuoqing ZhangKLKaiyuan LiZDZheng Ding

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Overview

Observational analysis reveals tumor source distinctions in esophageal squamous cell carcinoma, suggesting implications for treatment strategies.

Key Points

  • Whole-exome sequencing successfully differentiated between recurrent disease and a second primary tumor.
  • The initial and recurrent cervical lymph node malignancies shared comutations, indicating metastatic behavior.
  • Substantial regression of lymphadenopathy occurred after immunochemotherapy, highlighting treatment effectiveness.
  • Further investigation emphasizes the necessity for regular examinations of the remnant esophagus in ESCC patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5ac1https://doi.org/10.1007/s12672-025-03453-8
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