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October 9, 2025Frontiers in ImmunologyOpen Access

Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus

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Authors

XYXiaolei YinXLXiaopeng LiLMLili Mi

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Overview

Transcriptomic analysis uncovers distinct subtypes in SCCE tumors, highlighting immune evasion and microenvironment complexity.

Key Points

  • SCCE tumors display a predominance of malignant epithelial cells and significant immune suppression, impairing prognosis.
  • Single-cell RNA sequencing identified three transcriptionally distinct subtypes of malignant epithelial cells with varied differentiation.
  • The tumor microenvironment was enriched with extracellular matrix fibroblasts that show active collagen-driven signaling interactions.
  • A complex cell–cell communication network was revealed, highlighting the intricate interactions among cancer subtypes.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68e7ba40ccde5f1021f64a64https://doi.org/10.3389/fimmu.2025.1672587
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  1. 1138. MULTI-CENTER CLINICAL ANALYSIS AND SINGLE-CELL SEQUENCING INSIGHTS INTO THE DEVELOPMENTAL MECHANISMS OF SYNCHRONOUS MULTIPLE PRIMARY ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  2. 2Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma2025
  3. 3Small cell neuroendocrine carcinoma of the cervix: diagnostic challenges and emerging molecular insights <sup>†</sup>2025
  4. 4Comprehensive single-cell sequencing reveals the tumor microenvironment and tumor-specific characteristics in trachea squamous cell carcinoma2025
  5. 5Integrative analyses of single‐cell and bulk RNA sequencing reveal tumour microenvironment features associated with neoadjuvant immunochemotherapy response in oesophageal squamous cell carcinoma2025