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September 10, 2025Diseases of the Esophagus

Comprehensive Genomic and Transcriptomic Analyses Reveal Prognostic Stratification for Esophageal Squamous Cell Carcinoma

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Authors

BLBin Li

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Overview

Analysis reveals genetic markers and distinct prognosis categories for esophageal squamous cell carcinoma.

Key Points

  • Prognostic stratification identified distinct ESCC subtypes with varying clinical outcomes.
  • Mutation in the mucin family and APOBEC signature correlated with poorer prognosis in patients.
  • Activation of the epithelial-keratinization pathway linked to better prognosis and reduced recurrence rates.
  • Validation of S100A8/A9 complex as a critical marker for the epithelial-keratinization pathway.

Cite This Study

Bin Li (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b7c8https://doi.org/10.1093/dote/doaf061.265
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Also Consider

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  1. 1354. A GENOMIC ANALYSIS OF SQUAMOUS CELL CARCINOMA OF THE OESOPHAGUS FOLLOWING NEOADJUVANT CHEMOTHERAPY2025
  2. 2Molecular Subtypes of Esophageal Squamous Cell Carcinoma Driven by N- Glycosylation and Construction of a Machine Learning-Based Prognostic Model2025
  3. 3138. MULTI-CENTER CLINICAL ANALYSIS AND SINGLE-CELL SEQUENCING INSIGHTS INTO THE DEVELOPMENTAL MECHANISMS OF SYNCHRONOUS MULTIPLE PRIMARY ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  4. 4A nine-gene signature with potential targets for predicting the prognosis of patients with esophageal cancer2025
  5. 5Gene‐specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study2025 · 4 citations