Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 10, 2025Human GenomicsOpen Access

Integrative single-cell and bulk transcriptomic analysis reveals the landscape of T cell mitotic catastrophe associated genes in esophageal squamous cell carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

SLShuang LiTZTao ZhengNWNan Wang

Discussion

Loading...

Member takes

Overview

Integrative analysis reveals prognostic significance of T cell mitotic catastrophe in ESCC, indicating potential therapeutic targets.

Key Points

  • T cell mitotic catastrophe-associated genes were identified, highlighting their role in esophageal squamous cell carcinoma.
  • The prognostic risk model based on these genes effectively predicted patient outcomes and drug sensitivity.
  • Machine learning algorithms enhanced the model's ability to reveal tumor immune microenvironment heterogeneity.
  • Functional validation of SLF2 showed its potential as a therapeutic target by inhibiting migration and invasion of ESCC cells.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a869bhttps://doi.org/10.1186/s40246-025-00815-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity2025
  2. 2Molecular Subtypes of Esophageal Squamous Cell Carcinoma Driven by N- Glycosylation and Construction of a Machine Learning-Based Prognostic Model2025
  3. 3Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus2025
  4. 4475. COMPREHENSIVE GENOMIC AND TRANSCRIPTOMIC ANALYSES REVEAL PROGNOSTIC STRATIFICATION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  5. 5Identifying Key Epigenetic Modification-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma and CellularValidation2025