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September 10, 2025DiabetesOpen Access

Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function

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Authors

JKJuliette A. de KlerkRSRoderick C. SliekerWPW. E. Parker

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Overview

Single-nucleus RNA-seq analysis reveals differential lncRNA expression in diabetic kidney disease, highlighting TARID's critical role in podocyte function.

Key Points

  • TARID, a podocyte-specific lncRNA, is crucial for actin cytoskeleton reorganization in diabetic kidney disease.
  • Analysis identified 174 cell type-specific lncRNAs in the human kidney, with 54 differentially expressed in diabetic kidney disease.
  • Integrative analyses combined eQTL, GWAS for eGFR, and gene regulatory networks to pinpoint lncRNA roles.
  • Single-nucleus RNA-seq data contributed to understanding the impact of lncRNAs on kidney health in diabetes.

Cite This Study

Klerk et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784b66https://doi.org/10.2337/db25-0272
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<b>Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function</b>2025
  2. 2Revealing the regulatory role of lncRNAs SNHG1 and CRNDE on Th17/Treg imbalance in diabetic kidney disease2025
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  4. 4RENAL SINGLE-NUCLEAR TRANSCRIPTOMICS IDENTIFIES NOVEL THERAPEUTIC TARGETS IN A PRECLINICAL MODEL OF CHRONIC KIDNEY DISEASE.2025
  5. 5Identification of Key lncRNAs and ceRNA Regulatory Networks in Diabetes-Associated Cognitive Dysfunction2025