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September 10, 2025Clinical and Experimental MedicineOpen Access

Revealing the regulatory role of lncRNAs SNHG1 and CRNDE on Th17/Treg imbalance in diabetic kidney disease

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Authors

SHSeyed Amirhossein HosseiniPAParisa AjorlouPMPegah Mousavi

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Overview

This analysis identifies lncRNAs affecting Th17/Treg imbalance in diabetic kidney disease, suggesting their potential as biomarkers.

Key Points

  • CRNDE is upregulated in individuals with ESRD and T2D, impacting RORC and IL-17 gene expression.
  • SNHG1 was significantly downregulated in ESRD, microalbuminuria, and T2D patients, showing its regulatory role.
  • The study analyzed multiple datasets and validated findings with real-time PCR across 90 individuals.
  • These lncRNAs might serve as novel biomarkers for diagnosing and predicting outcomes in diabetic kidney disease.

Cite This Study

Hosseini et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d647975e0https://doi.org/10.1007/s10238-025-01802-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel Molecular Signatures of Peripheral Regulatory T Cells in Kidney Disease Associated With Type 1 Diabetes.2025
  2. 2FGD5-AS1 and Th1/Th2 imbalance in the progression of diabetic nephropathy: evidence from bioinformatic and experimental validation2025
  3. 3Identification and experimental validation of demethylation-related genes in diabetic nephropathy2025
  4. 4Investigating the metabolic reprogramming mechanisms in diabetic nephropathy: a comprehensive analysis using bioinformatics and machine learning2025 · 1 citations
  5. 5Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function2025