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September 10, 2025Open Access

Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function

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Authors

JKJuliette A. de KlerkRSRoderick C. SliekerWPW. E. Parker

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Overview

Observational analysis reveals cell type-specific lncRNAs in diabetic kidney disease, suggesting TARID's pivotal role in podocyte function.

Key Points

  • TARID's expression is critical for podocyte health, and its regulation may impact diabetic kidney disease.
  • The study identifies 54 differentially expressed lncRNAs in diabetic kidney disease, emphasizing their potential roles in kidney function.
  • Integrative analyses linked eQTL data and GWAS for eGFR to find key lncRNAs affecting renal health.
  • Single-nucleus RNA sequencing provided insights into the lncRNA landscape across kidney cell types, enhancing our understanding of renal biology.

Cite This Study

Klerk et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784b6chttps://doi.org/10.2337/figshare.29881751.v1
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