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August 16, 2025

Novel Molecular Signatures of Peripheral Regulatory T Cells in Kidney Disease Associated With Type 1 Diabetes.

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Authors

ABAmita BansalSWSoon Wei WongWWWilson K. M. Wong

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Overview

Assessment using flow cytometry and RNA-sequencing found altered Tregs in type 1 diabetes patients, indicating new insights into diabetic kidney disease.

Key Points

  • Regulatory T cells show significant changes in diabetic kidney disease, with alterations noted in their subsets and gene transcripts.
  • Machine-learning analyses revealed microRNAs correlated with clinical eGFR values, pinpointing their association with kidney function.
  • Tregs exhibited distinct molecular signatures when comparing participants with and without diabetic kidney disease.
  • Identified ligand genes on Tregs interacting with kidney cell receptors may clarify their role in diabetic kidney disease progression.

Cite This Study

Bansal et al. (2025) studied this question.

synapsesocial.com/papers/68a35140234c60ad5c20c96ahttps://doi.org/10.34067/kid.0000000921
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Also Consider

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  5. 5Integrating bioinformatics and machine learning to elucidate the role of protein glycosylation-related genes in the pathogenesis of diabetic kidney disease2025 · 4 citations