Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 10, 2025

Renal Single-Nuclear Transcriptomics Identifies Novel Therapeutic Targets in a Preclinical Model of Chronic Kidney Disease.

View Full Paper
Ask AI
Bookmark
Share

Authors

ACAlejandro ChadeSSSathesh K. SivasankaranRSRhys Sitz

Discussion

Loading...

Member takes

Overview

Single nucleus RNA sequencing reveals key targets in chronic kidney disease, highlighting angiogenesis and inflammation pathways.

Key Points

  • Chronic kidney disease (CKD) continues to rise, necessitating effective therapeutic strategies.
  • Single nucleus RNA sequencing identified 16 unique renal cell types, focusing on endothelial cell gene expression.
  • Five overlapping differentially expressed genes were found, implicating inflammation and fibrosis in CKD.
  • Modulating key genes like VWF and LAMA3 showed promise in reducing endothelial cell inflammatory responses.

Cite This Study

Chade et al. (2025) studied this question.

synapsesocial.com/papers/689e03d9d61984b91e13cb8bhttps://doi.org/10.34067/kid.0000000945
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Whole-transcriptome sequencing reveals key biomarkers and pathways in renal fibrosis2025
  2. 2Single-cell RNA sequencing revealed the association between proximal tubular epithelial cells and renal interstitial cells in chronic kidney disease progression2025
  3. 3Single-Cell Maps Reveal Novel Mechanisms of Ferroptosis and Biomarkers in Diabetic Nephropathy2025 · 1 citations
  4. 4Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets2026
  5. 5Identification of progression-related genes and construction of prognostic model for chronic kidney disease by machine learning2025