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September 10, 2025Current Analytical Chemistry

Identification of Key lncRNAs and ceRNA Regulatory Networks in Diabetes-Associated Cognitive Dysfunction

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Authors

YDYingying DengJHJuan HuYLYang Lan

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Overview

High-throughput sequencing reveals key lncRNAs linked to cognitive dysfunction in diabetes, suggesting regulatory pathways.

Key Points

  • Upregulated and downregulated lncRNAs and mRNAs were identified in diabetic mice, indicating distinct regulatory mechanisms.
  • The analysis revealed 36 lncRNA-mRNA pairs linked to 8 KEGG pathways, highlighting potential biological roles.
  • Gene Ontology and pathway enrichment analyses showed associations with inflammation, lipid metabolism, and growth.
  • qRT-PCR confirmed the increased expression of novel lncRNAs in diabetes, supporting their role in cognitive dysfunction.

Cite This Study

Deng et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d64791b12https://doi.org/10.2174/0115734110374941250717134147
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