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September 10, 2025Nucleosides Nucleotides & Nucleic Acids

Regulation of prognosis and tumor progression in cervical cancer by circ₀005728

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Authors

SZShanshan ZhangJiangxi University of Traditional Chinese MedicineXSXiyu ShenHCHongyin Cui

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Implication

Analysis identifies circ_0005728 as a crucial prognostic factor in cervical cancer, suggesting targeting miR-370-3p may influence tumor progression.

Key Points

  • High levels of circ_0005728 correlate with poor outcomes in cervical cancer patients.
  • Cox analyses revealed lymph node metastasis and circ_0005728 as independent prognostic factors.
  • Silencing circ_0005728 increased apoptosis in cervical cancer cells and diminished their proliferation.
  • MiR-370-3p is identified as a downstream target of circ_0005728 which modulates cancer cell functionality.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d64790dd6https://doi.org/10.1080/15257770.2025.2537168
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