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September 10, 2025MedicinaOpen Access

Curcumin as an Epigenetic Modulator: Suppression of Breast Cancer via the Hsacirc₀001946/MiR-7-5p/Target Gene Axis

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Authors

AAAsmaa AbuaıshaMKMurat KayaİSİlknur Süer

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Overview

Observational study reveals curcumin’s effects on the hsa_circ_0001946/miR-7-5p/target gene axis in breast cancer, suggesting new therapeutic targets.

Key Points

  • Curcumin significantly inhibited the proliferation and migration of breast cancer cells, and enhanced apoptosis.
  • Analysis showed that curcumin treatment reduced hsa_circ_0001946 and upregulated miR-7-5p in breast cancer cells.
  • Western blotting confirmed the downregulation of CKS2 protein after curcumin treatment in breast cancer cell lines.
  • Findings indicate a novel regulatory pathway involving hsa_circ_0001946 and may facilitate future breast cancer therapies.

Cite This Study

Abuaısha et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64785e48https://doi.org/10.3390/medicina61091600
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