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September 5, 2025Diabetology & Metabolic SyndromeOpen Access

Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway

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Authors

XPXiaoyan PeiLLLijuan LuZHZhendong Huang

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Overview

This research finds that M1 macrophage polarization boosts glycolysis in diabetic kidney disease, highlighting the HIF-1α-HK2 connection.

Key Points

  • M1 macrophage polarization significantly enhances glycolytic activity in diabetic kidney disease.
  • In rodent models, increased levels of HIF-1α and HK2 align with elevated macrophage polarization metrics.
  • Glycolytic metabolites showed substantial increases in both animal models and patient samples with diabetic kidney disease.
  • HIF-1α regulates HK2 transcription in M1 macrophages, linking polarization to enhanced glycolysis in diabetic kidney disease.

Cite This Study

Pei et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477ab1chttps://doi.org/10.1186/s13098-025-01894-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease2025 · 23 citations
  2. 2Hypoxia-Induced Metabolic Reprogramming in the Renal Tubules of Patients with Diabetic Kidney Disease and the Associated Traditional Chinese Medicine Intervention Strategies2025 · 12 citations
  3. 3Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis2026
  4. 4Long-term hyperglycaemia exerts contrasting effects on M1- and M2-like macrophages2025
  5. 5Mechanisms by which macrophage Ltb4r1 mediates tubular epithelial cell injury to facilitate the advancement of diabetic kidney disease2026