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September 10, 2025International Journal of Biological SciencesOpen Access

Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease

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Authors

HZHui ZhaoJGJia Guo

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Overview

This review highlights macrophages' role in inflammation and fibrosis in diabetic kidney disease, suggesting promising therapeutic strategies.

Key Points

  • Macrophages play a critical role in the progression of diabetic kidney disease, influencing inflammation and fibrosis.
  • Emerging research indicates that targeting macrophages could be a promising therapeutic approach for diabetic kidney disease with potential to delay progression.
  • Macrophages, integral to tissue repair and regeneration, could be crucial in developing innovative treatments for diabetic kidney disease.
  • Diabetic kidney disease is a leading cause of end-stage renal disease, highlighting the need for effective therapeutic strategies.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479aaf0https://doi.org/10.7150/ijbs.112737
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of macrophages in renal fibrosis and therapeutic prospects2025
  2. 2The multifaceted role of macrophages in kidney physiology and diseases2025
  3. 3Role of Nuclear Receptors, Lipid Metabolism, and Mitochondrial Function in the Pathogenesis of Diabetic Kidney Disease2025 · 17 citations
  4. 4Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions2025 · 32 citations
  5. 5Mesangial Cells in Diabetic Kidney Disease: From Mechanisms to Therapeutic Implications2025